Metabolism of coprostanol-C14 and cholestanol-4-C14 in man

Metabolism of Coprostanol-c14 and Cholestanol-4-c14 in Man.

Metabolism of L-ascorbic acid-1-C14 in man.

n-Ascorbic acid labeled with Cl4 has been utilized in studying the metabolism of this vitamin in rats (1, 2) and guinea pigs (3, 4). In both species there is considerable conversion of carboxyl-labeled n-ascorbic acid to CO2 and significant urinary excretion of labeled oxalate. The important nutritional role of n-ascorbic acid made it desirable to study the metabolism of the labeled vitamin in ...

The metabolism of glycine-2-C14 in man. III. The urinary excretion of C14 and cumulative radiation dosimetry.

Five patients were given 100 microcuries of glycine-2CH4 (8.0 mg.) intravenously; these do not include the four patients whose pulmonary C14 excreted has been reported (1). The time and volume of each spontaneous urinary voiding was noted for the first 10 days; thereafter an aliquot of a spontaneous morning voiding was collected once per week. An aliquot (5 or 10 ml.) was dried in vacuo, then c...

Metabolism of 21-deoxyhydrocortisone-4-C14 in man; 17-dehydroxylation, an artifact.

It has been claimed that 17-dehydroxylation was a pathway in the metabolism of 21-deoxyhydrocortisone and 17a-hydroxyprogesterone in man (1, 2). Such 17-dehydroxylation of corticoids in tivo without alteration in carbon skeleton appeared unlikely as a biochemical reaction? but from a consideration of chemical mechanisms there was a strong probability that the 17-deoxy metabolites were artifacts...

Absorption and metabolism of cortisone-4-C14 acetate.

Previous work in this laboratory with steroids labeled with Cl4 (l-10) has been extended to include the present experiments on the absorption and disposition of the radioactive carbon of cortisone-4-U4 acetate’ in the rat. Since the conditions of these experiments, i.e. solvent vehicle, strain and type of animal studied, operative techniques, method of collection of specimens, and Cl4 assay, di...